There’s really nothing quite like the unwavering feeling of bloat and upset stomach. Gastrointestinal issues can affect everything from your performance in the gym to your everyday health and wellness, keeping a tight grip on you and your overall quality of life. Nutrition is the key to optimizing your gut health and by integrating the right supplements into your daily routine, you’ll be able to improve your physical and mental wellness. Save this list of the 5 best supplements for gut health and inflammation. 

L-Glutamine 

L-glutamine is an extremely versatile and highly abundant conditionally essential amino acid. Several studies have shown that glutamine can improve gut health through several gut diverse and gut friendly mechanisms.

The pathology of gut related disease states such as Crohn's ulcerative colitis, inflammatory bowel disease, and leaky gut have been linked with intestinal hyperpermeability and relapsing inflammation of the gastrointestinal tract.

Studies have shown that glutamine is one of the best supplements for gut health and inflammation because it can restore gut permeability in patients with inflammatory bowel disease. Glutamine can rebuild the intestinal lining by regulating nitrogen balance and feeding the small mucosa of the gut to improve overall gut integrity [R, R]. Intestinal barrier integrity is essential for absorption of nutrients. Any type of dysfunction of the mucosal barrier is associated with gut hyper permeability. 

Glutamine also mitigates the stress response of proinflammatory cytokines. Crohn's and other forms of inflammatory bowel disease are correlated with systemic inflammation of the gastrointestinal tract, therefore, glutamine may help improve overall symptoms.

A healthy gut also requires a flourishing microbiome. The gut microbiome is a collective genome in the gut, populated my microorganisms called microbiota. Glutamine increases intestinal friendly microbiota, specifically Bacteroidetes and Actinobacteria while decreasing pernicious bacteria Oscillospira and Treponema, promoting better overall gut health. Including glutamine rich foods in your diet and adding an unflavored high-quality glutamine supplement to your daily routine, may substantially benefit and improve your gut health.  

Probiotics

Probiotics are perhaps the most popular supplements to nourish your gut health. Probiotics are live microorganisms that promote a healthy gut microbiome influencing immunity, appetite, and energy metabolism [R]. The bacteria, fungi, viruses, and other microorganisms that make up your body’s microflora actually outnumber your body’s cells 10 to 1 and recent research increasingly shows that they play a major role in both mental and physical health.

Probiotics help to fortify the intestinal barrier and suppressing the growth of pathogens. Probiotics produce antimicrobial agents or metabolic compounds that suppress the growth of other microorganisms or compete for receptors and binding sites with other intestinal microbes on the intestinal mucosa [R, R] Probiotic Lactobacillus strains improve the integrity of the intestinal barrier, which may result in improved digestion and immune health.

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Probiotics are packed with salubrious bacteria that create a healthy gut flora, or environment for a healthful digestive system. Probiotic rich foods such as greek yogurt, kombucha, apple cider vinegar and other fermented food such as kefir, and kimchi can improve gut health and improve your immune system.  

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Prebiotics (aka Fiber)

Prebiotics are simply non-digestible or insoluble fiber. Prebiotics are fermented in the gastrointestinal tract by beneficial bacteria in the colon, promoting a healthy gut microbiome. Prebiotics modulate gut microbiota and improve energy metabolism increasing mineral and micronutrient absorption and improving the intestinal barrier.

Insoluble fiber promotes the movement of material through your digestive system and increases bowel movement. Essentially, it’s like a broom that sweeps your system, so you can easily pass bowel movements on a consistent basis. If you don’t get enough insoluble fiber in your diet, you can have symptoms such as irregular bowel movement and constipation.

Soluble fiber comes from oats, peas, beans, and the fleshy part of fruits and veggies such as apples, carrots and citrus fruits and partially ferments in your gut. As it dissolves, it forms a gel-like material that passes through the GI tract slowing digestion and allowing better nutrient absorption.

If you want to improve your gut health start adding some fiber rich foods to your diet.

Apple Cider Vinegar

Apple cider vinegar is one of the best supplements for gut health and inflammation because it helps increase the acidity of the stomach, in turn helping your body create more pepsin, the digestive enzyme that breaks down protein in the digestive tract [R] The real benefit comes from improving stomach acid production, which is crucial for the digestive process of the foods that we eat. When people don’t make enough stomach acid naturally, this can lead to uncomfortable bloating and gas. ACV serves as a nice, natural home remedy for bloating and digestive symptoms. Apple cider vinegar is both rich in probiotics as well as acetic acid, which can potentially benefit digestion and gut health. If you can’t stomach the actual vinegar, grab yourself some ACV Gummies.

Collagen

Collagen is a structural protein, specifically a polypeptide containing a mixture of the amino acids glycine, proline, and lysine. As one of the most abundant proteins in the human body, Collagen consists of nearly one-third or 30% of total human protein [R]. Collagen is engrained within the connective tissue of animals and humans, specifically found in the cartilage, tendons, muscles, and bones. Collagen is essentially the glue that holds everything together. Collagen is rich in foods such as bone broth, egg whites, and citrus fruits may improve and promote collagen production.

There have been several health claims that collagen peptides may promote better gut health, by improving gut lining permeability. Some preliminary studies have suggested a collagen and gut connection, showing that collagen may suppress epithelial gut barrier dysfunction and thus improving intestinal lining [R].

Research suggests that collagen may benefit those with inflammatory bowel disease such as ulcerative colitis, leaky gut, and Crohn's by reducing inflammation, essentially restoring gut lining and connective tissue within the GI tract. Patients with IBD are found to have lower serum collagen concentrations [R]. Supplementing with Collagen may therefore improve gut permeability and improve gut health.

Best Supplements For Gut Health: Takeaway

Gut health can have a profound impact on your physical and mental wellbeing. Your gut is connected to every physiological aspect of your body, including your brain, joints, mood, and health. By reducing inflammatory foods and implementing the best supplements for gut health such as glutamine, probiotics, and collagen into your diet, you can improve your gut health and overall wellbeing from the inside out. 

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References

Liu, Yulan et al. “Therapeutic Potential of Amino Acids in Inflammatory Bowel Disease.” Nutrients vol. 9,9 920. 23 Aug. 2017, doi:10.3390/nu9090920

Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F, Wu Z. Glutamine and intestinal barrier function. Amino Acids. 2015 Oct;47(10):2143-54. doi: 10.1007/s00726-014-1773-4. Epub 2014 Jun 26. PMID: 24965526.

Valdes A M, Walter J, Segal E, Spector T D. Role of the gut microbiota in nutrition and health BMJ 2018; 361 :k2179 doi:10.1136/bmj.k2179

Chen Q, Chen O, Martins IM, Hou H, Zhao X, Blumberg JB, Li B. Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct. 2017 Mar 22;8(3):1144-1151. doi: 10.1039/c6fo01347c. PMID: 28174772.

Koutroubakis IE, Petinaki E, Dimoulios P, Vardas E, Roussomoustakaki M, Maniatis AN, Kouroumalis EA. Serum laminin and collagen IV in inflammatory bowel disease. J Clin Pathol. 2003 Nov;56(11):817-20. doi: 10.1136/jcp.56.11.817. PMID: 14600124; PMCID: PMC1770111.