Citrulline Malate: 3 Clinically Proven Benefits Of Citrulline Malate And How It Can Improve Your Training

CrossFit and other high-intensity sports, impose a huge demand for aerobic and anaerobic capactiy, strength, and energy production. Imagine if you could perform an entire workout and never experience one bout of muscle fatigue the entire time. You could easily knock out more reps, you would optimize training times, you would gain more lean muscle mass, and your endurance would be through the roof. One of the many clinically proven benefits of Citrulline Malate (CM) is the ability to increase training volume through the delayed onset of muscle fatigue. Muscle fatigue is perhaps the most incapacitating component of your training. Working out completely fatigue free might be stretching it, but reducing muscle fatigue and adding in a few more reps can provide a dramatic difference in your overall performance.

What Is Citrulline Malate?

Citrulline Malate is a unique combination of the nonessential amino acid L-Citrulline and malate, which comes from malic acid. L-Citrulline is derived from watermelons while Malate is taken from the Latin word mālum, meaning “apple.” Vegans, go ahead and raise the roof! Citrulline Malate has been used now for over 20 years in Europe as a pharmacological treatment for fatigue, muscle weakness, and dementia. Only recently, has Citrulline Malate been offered for commercial use in sports performance and supplementation. 

Benefits of citrulline malate - swolverine

What Does Citrulline Malate Do?

L-Citrulline can be naturally obtained one of two ways. One is from diet and two, your body can manufacture it from l-ornithine another amino acid through a biochemical process called the urea cycle. The urea cycle helps your body get rid of ammonia, a waste product of protein digestion. When your digestive system metabolizes Citrulline Malate, enzymes in your liver convert it into arginine, where it is then converted into Nitric Oxide (NO). Therefore, Citrulline Malate supplementation raises ornithine and arginine plasma content, which improves the ammonia recycling process and nitric oxide metabolism. 

The Benefits Of Citrulline Malate

1. Citrulline Malate Helps Reduce Muscle Fatigue And Optimize Endurance

One of the greatest benefits of Citrulline Malate is in it’s proven ability to help delay muscle fatigue, by promoting an increase in aerobic energy production. A study published in the British Journal Of Sports Medicine, found that 6g of Citrulline Malate taken daily, reduced muscle fatigue, by producing a 34% increase in the rate of oxidative ATP production during exercise. The study also found a 20% increase in the rate of phosphocreatine recovery after exercise, indicating a larger contribution of oxidative ATP synthesis to energy production. [R] Thus, Citrulline Malate supplementation can help you fight muscle fatigue, due to the increase in ATP production and phosphocreatine release after exercise. When you’re competing at an elite level, generating more energy can provide a sustainable impact on your athletic performance.

2. Citrulline Malate Helps Relieve Muscle Soreness And Improves Recovery 

Muscle soreness can cause extreme physical discomfort and interrupt training sessions. With a reduction in acute muscle soreness and post-workout muscle breakdown, you can increase training volume, and generate greater gains in strength and overall performance. One of the greatest benefits of Citrulline Malate is optimizing post-workout muscle soreness, so you can recover faster. 

In a study, published in the Journal Of Strength and Conditioning Research, at the University of Córdoba, Spain 41 male participants performed two consecutive flat barbell bench-training sessions for a total of sixteen sets. 8g of Citrulline Malate were administered during one of the first two sets and placebo was administered for the third. The subjects' resistance was tested using the repetitions to fatigue test at 80% of their predetermined one rep max in the 8 sets of bench presses during the training session. The number of reps showed a significant increase from placebo treatment to treatment with Citrulline Malate from the third set achieving 52.92% more repetitions. The study also showed a 40% reduction in muscle soreness at 24 hours and 48 hours with a response rate greater than 90% with Citrulline Malate supplementation. [R] Again, this study proves that one of the greatest benefits of Citrulline Malate is reducing muscle fatigue, in addition to optimizing post-workout recovery.

SWOLVERINE - Citrulline Malate Improvements in Strength

SWOLVERINE - Citrulline Malate Helps Post Workout Muscle Soreness

3. Citrulline Malate Benefits Greater Gains In Strength 

Citrulline Malate has proven to have significant benefits on increasing strength through different mechanisms of action.

Citrulline Malate Enables Nitric Oxide Production

One of the biggest benefits of Citrulline Malate is its ability to influence Nitric Oxide (NO) production through a rise in plasma L-Arginine levels. Nitric Oxide is a vasodilator, therefore widening blood vessels, increasing blood flow and circulation without increasing blood pressure. That means better muscle repair, faster recovery, and increased strength.

Citrulline Malate Facilitates Protein Synthesis

With higher levels of L-Arginine, Citrulline Malate also facilitates the biological process of protein synthesis, where cells generate new proteins. During this process, amino acids are absorbed into muscle cells, leading to an increase in blood insulin levels to maintain and increase muscle mass and strength. High-intensity training causes muscle anabolism and catabolism, (buildup and breakdown) of muscle tissue. Therefore, facilitating the process of protein synthesis will help produce and maintain muscle mass and strength.

Citrulline Malate Influences Amino-Acid Utilization

Yet another amazing benefit of Citrulline Malate, is the ability to enhance the body’s use of amino acids during exercise.

In a study published in the European Journal of Applied Physiology, 17 pre-professional male cyclists were administered 6g of Citrulline Malate two hours prior to exercise and participated in a 137-km cycling stage. Results from blood tests indicated that most essential amino acids significantly decreased their plasma concentration as a result of exercise; however, most non-essential amino acids tended to significantly increase their concentration. Citrulline Malate also significantly increased the plasma concentration of citrulline, arginine, ornithine, urea, creatinine, and nitrite, with a significant increase in growth hormone. This study proves that Citrulline Malate actually enhances the body’s use of amino acids, especially branched-chain amino acids during high-intensity training [R

What's The Recommended Dose Of Citrulline Malate?

To enhance sports performance, 5-8g of Citrulline Malate should be supplemented within an hour of high-intensity training.

Benefits Of Citrulline Malate: Conclusion

Through extensive pharmacological use and clinical research, Citrulline Malate is proven to be one of the most effective supplements in sports performance to help fight fatigue, increase strength, and improve recovery. If you want to increase your training volume and endurance, adding Citrulline Malate to your daily supplement and nutrition regimen will help you reach your goals. With an increased training volume your gains in strength and endurance compound over time, to increase overall athletic performance. 

Looking To Add Citrulline Malate In Your Supplement Regimen To Crush Your Workout Performance?

Swolverine's Citrulline Malate is a synergistic 2:1 ratio of L-Citrulline a nonessential amino acid and malic acid. Citrulline Malate naturally promotes the production of nitric oxide (NO), which supports greater endurance, muscle force, power, and delays muscle fatigue* Citrulline Malate is proven to help promote strength, improve endurance, and optimize muscle recovery. 

We believe that everyone can optimize not only their athletic performance but their human potential. The way we believe we can optimize performance is through transparency, clinically effective doses, and clinically proven ingredients with evidence-based outcomes. We provide the nutrients you need to power your active lifestyle. 



Bendahan D, Mattei JP, Ghattas B, et al Citrulline/malate promotes aerobic energy production in human exercising muscleBritish Journal of Sports Medicine 2002;36:282-289.

Pérez-guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010;24(5):1215-22.

Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010;110(2):341-51. 

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