If you’ve ever hit a plateau with traditional anabolic strategies — whether you’re using SARMs, peptides, or steroids — and still want more from your recovery, lean muscle growth, or fat loss, IGF-1 LR3 might be what bridges the gap.
This powerful synthetic peptide offers a unique ability to stimulate new muscle cell formation (hyperplasia) while accelerating recovery and improving performance — all with minimal androgenic risk. Unlike HGH, IGF-1 LR3 acts directly on tissues, bypassing the liver, and delivers faster, more targeted growth effects — making it a favorite in both cutting and lean bulking cycles.
IGF-1 LR3 has quickly gained traction among men and women looking to:
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Accelerate muscle recovery
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Add dense, lean tissue
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Preserve muscle during cutting
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Rebuild after a cycle or injury
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Improve performance without androgenic side effects
In this guide, we’ll break down exactly how IGF-1 LR3 works, what benefits you can expect, and provide gender-specific cycle protocols — plus how to stack it effectively with peptides like MK-677 or BPC-157, and the best supplement support for maximizing gains.
Whether you’re entering a lean bulk, recovering from a cutting cycle, or simply trying to stay anabolic year-round, this science-backed breakdown will show you how to run IGF-1 LR3 safely and effectively — without wasting time or money.
What Is IGF-1 LR3?
IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic peptide engineered to enhance the anabolic effects of natural IGF-1 while significantly extending its half-life. IGF-1 itself is a hormone similar in structure to insulin and plays a critical role in muscle growth, cell repair, and tissue regeneration.
Unlike native IGF-1 — which has a short half-life of only 20–30 minutes — IGF-1 LR3 has been modified by replacing the third amino acid with arginine and extending the peptide chain by 13 additional amino acids. This results in a half-life of up to 30 hours, allowing for prolonged anabolic activity and greater biological potency.
By resisting binding to IGF-binding proteins (IGFBPs), IGF-1 LR3 remains free in the bloodstream longer, which increases its ability to activate IGF-1 receptors in muscle tissue. Once bound, it triggers the PI3K/Akt/mTOR pathway, stimulating protein synthesis and muscle cell proliferation.
"IGF-1 LR3 was designed to have a longer half-life and reduced affinity for IGFBPs, resulting in greater mitogenic and anabolic effects compared to native IGF-1."
— Junnila et al., Nature Reviews Endocrinology
IGF-1 LR3 is not the same as HGH (Human Growth Hormone) — but the two are related. HGH stimulates the liver to produce endogenous IGF-1, whereas IGF-1 LR3 bypasses the liver and acts directly on tissues, making it faster-acting and more targeted in its effects.
"While HGH induces systemic IGF-1 production through hepatic stimulation, IGF-1 LR3 offers direct receptor activation and longer bioavailability, leading to more efficient muscle growth."
— Clemmons, Growth Hormone & IGF Research
How IGF-1 LR3 Works in the Body
IGF-1 LR3 promotes growth and recovery by binding to IGF-1 receptors located on skeletal muscle, organ, and nerve cells — triggering the PI3K/Akt/mTOR pathway. This cascade leads to increased protein synthesis, cell proliferation, and glucose uptake.
Unlike anabolic steroids that primarily increase the size of existing muscle fibers (hypertrophy), IGF-1 LR3 may also promote hyperplasia — the formation of new muscle cells — a potential advantage for long-term growth.
IGF-1 LR3 also supports:
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Enhanced insulin sensitivity: By mimicking insulin-like action, IGF-1 LR3 improves glucose transport into muscle cells, aiding in nutrient partitioning and glycogen storage — especially when paired with post-workout carbs and protein like Swolverine Whey Isolate.
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Accelerated recovery: IGF-1 promotes repair and regeneration of damaged tissue, making it valuable post-injury or following intense hypertrophy training.
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Fat oxidation: Elevated IGF-1 levels are associated with increased fat metabolism and lean mass preservation during caloric deficits — making it a popular choice during cutting cycles.
"Activation of the IGF-1 receptor stimulates a cascade that promotes anabolic activity, glucose uptake, and inhibition of apoptosis in muscle cells."
— Le Roith et al., Endocrine Reviews
Because IGF-1 LR3 acts independently of the liver (unlike HGH), it produces localized and systemic growth effects without relying on conversion — which means more consistent outcomes across users. This also makes it a popular stacking option alongside peptides like BPC-157, MK-677, or traditional testosterone-based anabolic cycles.
Benefits of IGF-1 LR3 for Men and Women
While IGF-1 LR3 works through the same biological mechanisms in all users, the benefits can be tailored and optimized based on your training phase, physique goals, and sex-specific hormonal profile.
Benefits for Men
1. Increased Lean Muscle Mass
IGF-1 LR3 stimulates both hypertrophy and hyperplasia, meaning it can increase the number of muscle cells — not just their size. This makes it an ideal tool for long-term muscle density, especially when stacked with testosterone or anabolic SARMs like LGD-4033 (Ligandrol).
"IGF-1 activates satellite cells and stimulates muscle fiber regeneration, resulting in functional hypertrophy and potentially hyperplasia."
— Barton-Davis et al., PNAS
2. Enhanced Recovery Between Workouts
IGF-1 LR3 speeds up muscle tissue repair and reduces soreness, making it particularly useful during high-volume training or CrossFit-style programming. When combined with nutrients from Swolverine INTRA, it further supports hydration and cellular energy restoration.
3. Increased Nutrient Partitioning
By improving insulin sensitivity and glucose uptake, IGF-1 LR3 helps shuttle nutrients directly into muscle tissue instead of fat. This makes it highly synergistic with a clean bulking phase supported by high-protein meals and Swolverine Whey Protein Isolate.
4. Joint and Connective Tissue Repair
IGF-1 plays a key role in tendon and ligament recovery, which can be further supported with Swolverine Collagen Protein and BPC-157 protocols for deeper healing and injury prevention.
Benefits for Women
1. Recomposition Without Androgenic Risk
Unlike anabolic steroids, IGF-1 LR3 is non-androgenic, meaning it won’t cause masculinizing side effects like voice deepening or facial hair. For women, this makes it ideal for body recomposition — promoting lean muscle gain while preserving feminine physique and hormonal balance.
"IGF-1 administration in women enhances lean mass and decreases fat mass without significant androgenic changes."
— Davis et al., The Journal of Clinical Endocrinology & Metabolism
2. Muscle Tone and Firmness
IGF-1 LR3 supports subtle increases in muscle tone, particularly in the glutes, shoulders, and legs — without significant weight gain or bloating. This makes it popular for fitness competitors and women entering a mini-cut.
3. Faster Recovery From Training or Injury
Women tend to experience more joint laxity and soft tissue injuries, especially during menstruation. IGF-1 LR3 can help accelerate repair and reduce downtime. Recovery is enhanced when paired with high-quality sleep support like Swolverine ZMT, which supports natural testosterone and growth hormone production.
4. Skin, Hair, and Collagen Support
Because IGF-1 increases collagen synthesis and cell turnover, many users report improved skin elasticity, reduced fine lines, and thicker hair — especially when combined with Swolverine Collagen and a micronutrient-rich diet.
Best IGF-1 LR3 Cycle Protocols for Men and Women
Because of its long half-life and direct anabolic signaling, IGF-1 LR3 is most effective when cycled with purpose. While both men and women can use it for muscle growth, recovery, or recomposition, dosing and cycle length should differ based on body size, hormonal sensitivity, and overall goal.
Below are optimal, real-world dosing protocols used by athletes and supported by clinical research and anecdotal reports.
Cycle Protocol for Men
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Dosage: 20–40 mcg per day
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Frequency: Daily, 5–7x/week
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Timing: Immediately post-workout (or fasted AM on rest days)
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Cycle Length: 4–6 weeks standard, up to 8 weeks with breaks
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Injection Site: Subcutaneous or intramuscular, often rotated (arms, legs, glutes)
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Goal Phases: Recomp, lean bulking, recovery/PCT
Example Cycle (6 Weeks):
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Weeks 1–6: 30 mcg IGF-1 LR3 post-workout daily
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Paired with: Swolverine Whey Isolate, INTRA, and Collagen
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Stack potential: Low-dose testosterone, MK-677, or SARMs like LGD-4033
"Short-duration IGF-1 administration post-exercise enhances muscle protein synthesis and supports long-term muscle hypertrophy when used adjunctively with resistance training."
— Fryburg et al., American Journal of Physiology
Cycle Protocol for Women
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Dosage: 10–20 mcg per day
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Frequency: 4–5x/week preferred (to allow better hormonal regulation)
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Timing: Post-workout or morning before first meal
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Cycle Length: 3–4 weeks standard; 5–6 weeks max with breaks
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Injection Site: Subcutaneous preferred for consistent delivery
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Goal Phases: Recomp, injury recovery, performance support
Example Cycle (4 Weeks):
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Weeks 1–4: 15 mcg IGF-1 LR3 post-workout, 5x/week
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Paired with: Swolverine ZMT for hormone and sleep support, Collagen, and clean carb/protein intake
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Stack potential: MK-677 (low dose), or run as a solo peptide for clean recovery
"Short-term IGF-1 treatment in healthy female subjects improved lean body mass without significant androgenic changes."
— Davis et al., The Journal of Clinical Endocrinology & Metabolism
Both men and women should avoid exceeding 8 weeks of continuous IGF-1 LR3 use without taking a break, as prolonged elevation may increase insulin desensitization or desensitize receptors. Cycling on/off and integrating with peptides like BPC-157 or L-Glutamine can support joint repair and gut health during the off-phase.
How to Stack IGF-1 LR3 with Other Compounds
IGF-1 LR3 is one of the most stackable compounds in a performance enhancement protocol. Its non-hormonal nature, long half-life, and direct action on muscle tissue make it an ideal foundation for growth, recovery, or body recomposition — especially when paired with other peptides, SARMs, or anabolic compounds.
1. IGF-1 LR3 + MK-677 (Ibutamoren)
This is a classic growth stack: MK-677 boosts your natural GH/IGF-1 production by stimulating the pituitary gland, while IGF-1 LR3 delivers immediate and sustained activation of IGF receptors in muscle tissue.
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MK-677 dosage: 10–25 mg daily
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Stack goal: Recomp, lean bulk, injury recovery
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Timing: MK-677 in the evening for GH pulse; IGF-1 LR3 post-workout or AM
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Support: INTRA for electrolytes, Collagen for connective tissue
2. IGF-1 LR3 + Testosterone (or SARMs)
When stacked with testosterone or anabolic SARMs like LGD-4033 or RAD-140, IGF-1 LR3 enhances muscle density and accelerates protein synthesis — especially post-cycle or while tapering down androgens.
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Goal: Muscle preservation, PCT bridge, long-term mass building
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Timing: IGF-1 LR3 post-workout; anabolic administered per its half-life
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Support: ZMT for natural hormone regulation, L-Glutamine for recovery
"The combination of IGF-1 and anabolic steroids has been shown to produce a synergistic effect on muscle hypertrophy and strength gains."
— Bamman et al., Journal of Applied Physiology
3. IGF-1 LR3 + BPC-157 or TB-500
This is a healing and regeneration stack, ideal for athletes recovering from injury, surgery, or connective tissue stress. IGF-1 drives muscle repair, while BPC-157 and TB-500 accelerate angiogenesis, tendon healing, and inflammation reduction.
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Goal: Joint and muscle regeneration
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Timing: IGF-1 LR3 post-workout; BPC-157/TB-500 injected near injury site or systemically
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Support: Collagen, L-Glutamine, Vitamin D3
4. IGF-1 LR3 as a Standalone Post-Cycle Bridge
After a steroid or SARM cycle, running a low-dose IGF-1 LR3 bridge can help retain muscle, enhance recovery, and keep strength levels elevated while hormones normalize — especially when paired with natural support supplements like ZMT and DHEA.
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Duration: 4–6 weeks post-PCT
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Dose: 20–30 mcg/day for men, 10–15 mcg/day for women
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Goal: Preserve lean mass, reduce catabolism, support hormonal rebound
Nutrition and Supplement Support
IGF-1 LR3 is powerful — but it’s not magic. To fully harness its effects, your nutrition, recovery, and supplement stack must support its metabolic demands. Without adequate calories, protein, micronutrients, and hydration, you risk blunting its anabolic potential or wasting your cycle entirely.
Prioritize Protein Intake for Muscle Growth
IGF-1 LR3 accelerates protein synthesis, but that process relies on having enough dietary amino acids available. Aim for 1.0–1.2g of protein per pound of bodyweight daily, with special emphasis on leucine-rich meals post-injection.
For convenience and absorption, use a clean, fast-digesting protein source like Swolverine Whey Isolate immediately after training or dosing.
Strategic Carbohydrate Timing
Insulin and IGF-1 are synergistic — they both signal growth and nutrient storage. Consuming a moderate-to-high glycemic carb source post-workout can enhance the cellular uptake of IGF-1 LR3, promoting glycogen restoration and tissue repair.
On training days, include intra-workout hydration like Swolverine INTRA, which provides electrolytes, glutamine, and taurine to improve endurance and rehydration.
Clean Carbohydrates for Sustained Growth
Swolverine offers two ideal options:
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Clean Carbs™ — made from whole food sources like sweet potatoes, yams, oats, and blueberries
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Clean Carbs + Creatine Stack — pairing Clean Carbs™ with Creatine Monohydrate can amplify cellular volume, strength, and recovery on IGF-1 LR3 cycles.
Use Clean Carbs:
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Post-workout alongside Swolverine Whey Isolate
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Pre-training to support performance and blood glucose balance
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With breakfast or midday meals to stabilize energy and prevent muscle breakdown
Micronutrient Support for Hormonal Health
We recommend daily use of:
"Zinc, magnesium, and vitamin D3 deficiencies have been associated with reduced IGF-1 secretion and testosterone levels in athletes."
— Cinar et al., Nutrients
Joint, Tendon, and Gut Recovery
Stack with:
Potential Side Effects and Safety
IGF-1 LR3 is often described as one of the "cleaner" enhancement compounds — and compared to anabolic steroids, that’s true. It doesn’t suppress endogenous testosterone, doesn’t aromatize into estrogen, and carries no direct androgenic side effects. But because it modifies cellular growth, it’s critical to use it with caution, awareness, and responsible cycle lengths.
Here are the most common side effects and safety considerations for both men and women.
1. Hypoglycemia (Low Blood Sugar)
Because IGF-1 mimics insulin, it can cause increased glucose uptake into cells — which, without adequate carb intake, may lead to symptoms of hypoglycemia (shakiness, fatigue, dizziness).
Prevent it with:
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Adequate post-injection carbs (e.g., Clean Carbs™)
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Avoiding fasted training unless specifically adapted
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Monitoring symptoms if using with insulin, MK-677, or low-carb diets
"IGF-1 activates insulin-like receptors and enhances glucose disposal, potentially lowering blood glucose when not balanced with nutrition."
— Clemmons, Trends in Endocrinology & Metabolism
2. Injection Site Irritation
While rare, some users report redness or irritation at the injection site — especially with subcutaneous delivery. This can often be avoided with proper rotation of sites, sterile injection practices, and avoiding repeated injections in the same area.
3. Insulin Resistance (If Misused Long-Term)
Paradoxically, while IGF-1 LR3 can improve insulin sensitivity when used properly, chronic overuse may lead to receptor desensitization and eventual insulin resistance — especially when paired with poor diet.
To avoid this:
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Cycle IGF-1 LR3 for no more than 6–8 weeks
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Take 4–6 weeks off before beginning another cycle
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Support insulin function with L-Glutamine, INTRA, and nutrient-dense meals
4. Organ Growth Concerns at High Doses
Because IGF-1 acts on all tissue — not just muscle — megadosing for extended periods may promote organ tissue hypertrophy, including intestinal walls and heart tissue. This is not a concern at standard dosages (10–40 mcg/day) for under 8 weeks, but should be avoided by those with a history of cancer or uncontrolled growth conditions.
"Chronic elevation of IGF-1 is associated with increased tissue growth, including non-muscular tissues. However, these effects are typically dose-dependent and reversible."
— Yu et al., Journal of Clinical Oncology
5. Menstrual Irregularities in Women (Rare)
While IGF-1 LR3 is not androgenic, some women may notice minor shifts in menstrual timing or libido, especially when used alongside SARMs or aggressive training. These effects are typically subtle, short-lived, and reversed after the cycle ends.
Used responsibly — with adequate nutrition, breaks between cycles, and support from supplements like ZMT, Multivitamin, and Vitamin D3 — IGF-1 LR3 offers a powerful tool for performance without harsh hormonal disruption.
Post-Cycle Therapy (If Stacked)
If you’re using IGF-1 LR3 as a standalone compound, you typically don’t need traditional post-cycle therapy (PCT). It doesn’t suppress natural testosterone production or interfere with estrogen balance. However, if you’re stacking IGF-1 LR3 with:
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Anabolic steroids
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Suppressive SARMs
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MK-677 at high doses
... a targeted PCT may be required to restore natural hormone levels and metabolic balance.
When You Need PCT
You should implement a PCT protocol if your cycle included:
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Exogenous testosterone or other anabolic steroids
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High-dose MK-677
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Any multi-compound stack where hormonal suppression is likely
Key PCT Goals
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Restore endogenous testosterone production
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Support HPTA (hypothalamic-pituitary-testicular axis) recovery
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Balance estrogen and DHT metabolism
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Reinforce insulin sensitivity and metabolic health
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Protect muscle gains with anti-catabolic support
Swolverine-Backed PCT Supplement Protocol
To support these goals naturally, consider stacking:
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ZMT — Contains zinc, magnesium, vitamin B6, DIM, ashwagandha, and Tongkat Ali to support testosterone, lower cortisol, and enhance sleep recovery.
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DHEA (100 mg/day) — Supports androgen recovery, mood, and libido as natural hormone levels normalize post-cycle.
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Vitamin D3 — Aids in testosterone production, immune function, and cellular health.
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Multivitamin — Replenishes critical micronutrients depleted during intense training or chemical enhancement.
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L-Glutamine — Supports gut health, muscle repair, and metabolic resilience during transition.
"Supplementation with zinc, D-aspartic acid, magnesium, and adaptogens has been shown to restore hormonal balance and improve recovery outcomes after anabolic cycles."
— Toprak et al., Biological Trace Element Research
Even if you aren’t using harsh compounds, supporting your body during and after any enhancement phase — including with IGF-1 LR3 — will reduce fatigue, improve mood, and preserve your hard-earned progress.
Legal Status and Disclaimer
IGF-1 LR3 is classified as a research chemical, not a dietary supplement or approved medication. While it is available for purchase online, its use in humans is not FDA-approved in the United States and it is not legal for over-the-counter or prescription use unless part of a clinical trial.
United States
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FDA: IGF-1 LR3 is not approved for human use and is designated for research purposes only.
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DEA: It is not a controlled substance, but its distribution and marketing for bodybuilding or athletic use is illegal.
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WADA (World Anti-Doping Agency): IGF-1 and all analogs, including LR3, are prohibited substances under the S2 category (Peptide Hormones, Growth Factors, and Related Substances). Athletes subject to drug testing should avoid IGF-1 LR3 entirely.
"The use of IGF-1 or its analogs for performance enhancement is banned in competitive sports and poses potential health risks when used without clinical supervision."
— World Anti-Doping Agency (WADA)
International Use
Laws vary by country. In some regions, peptides like IGF-1 LR3 may be regulated more strictly or banned outright. Always verify your local laws before purchasing, possessing, or using this compound.
Disclaimer
This article is for informational and educational purposes only. It does not constitute medical advice, and Swolverine does not endorse or promote the use of IGF-1 LR3 or any performance-enhancing drugs. Always consult with a qualified medical professional before beginning any new supplement or enhancement protocol.
Conclusion
IGF-1 LR3 is a powerful, highly targeted peptide that offers athletes and physique-focused individuals the potential to:
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Build lean muscle
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Accelerate recovery
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Optimize nutrient utilization
— all without the hormonal suppression risks of anabolic steroids.
Whether you're male or female, the key to success lies in:
✅ Proper dosing
✅ Smart stacking
✅ Complete support through nutrition and supplementation
Recap:
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How it works: Activates the IGF-1 receptor, triggering muscle cell proliferation and enhancing glucose uptake.
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Dosing: Men — 20–40 mcg/day for 4–6 weeks; Women — 10–20 mcg/day over shorter cycles.
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Stacking: Works well with MK-677, testosterone, or BPC-157 depending on your goals.
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Support: Optimal results require smart nutrition — including Whey Isolate, Clean Carbs™, INTRA, and joint or hormone support from ZMT, DHEA, and Collagen Protein.
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PCT: If stacking with suppressive compounds, a full PCT protocol using ZMT, Multivitamin, and Vitamin D3 is strongly recommended.
Used responsibly, IGF-1 LR3 can be a bridge between performance and longevity — offering strength, structure, and recovery without the side effects of harsher agents.
Want to maximize your next cycle?
👉 Explore Swolverine’s full line of performance-focused recovery supplements here.
